Scientific activity

multilateral cooperation has already brought about a number of important joint publications.

Since 2016 our team members have published more than 50 publications in both national and international peer-review journals related to the preclinical studies and clinical trials. The research and development center has been implementing long-term collaborative scientific projects with a number of national and foreign research centers as well as with industry.This multilateral cooperation has already brought about a number of important joint publications.

 

Our team plays a significant role both in clinical and preclinical studies in the field of cardiology interventional and cardio surgery. The most important articles in which the members of our team took part have been published in such prestigious magazines as The Lancet, EuroIntervention and Circulation.

Our research work includes evaluation of local administration of drugs in arteriosclerosis and in the prevention of restenosis after angioplasty procedures, investigation for preventing myocardial reperfusion injury after angioplasty, as well as methods for myocardial regeneration and vessel regeneration after cardiac infarction.

 

We develop and test novel methods of valve reparation and percutaneous heart valve implantation, new intravascular stents including biodegradable stents, and novel techniques of interventional treatment of hypertension.

Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.

Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski KP, Gasior P, Buszman PP, Buszman P, Jahangiri M, Shanahan CM, Hill J, Mayr M.Suna G, et al.Circulation. 2018 Jan 9;137(2):166-183. doi: 10.1161/CIRCULATIONAHA.116.023381. Epub 2017 Oct 13.Circulation. 2018.PMID: 29030347Free PMC article.

A Nuclear Magnetic Resonance Spectroscopy as a Method for Evaluation of In Vivo Poly-l-Lactide Biodegradation Kinetics From Stent-Polymer Matrices: An Experimental Study Utilizing Porcine Model of In-Stent Restenosis.

Orlik B, Buszman PP, Krauze A, Gąsior P, Desperak P, Pająk J, Kasperczyk J, Janas A, Jelonek M, Handzlik-Orlik G, Buszman PE, Milewski K.Orlik B, et al.J Cardiovasc Pharmacol Ther. 2016 Jan;21(1):93-9. doi: 10.1177/1074248415583091. Epub 2015 May 5.J Cardiovasc Pharmacol Ther. 2016.PMID: 25944843

Comparable vascular response of a new generation sirolimus eluting stents when compared to fluoropolymer everolimus eluting stents in the porcine coronary restenosis model.

Buszman PP, Michalak MJ, Pruski M, Fernandez C, Jelonek M, Janas A, Savard C, Gwiazdowska-Nowotka B, Żurakowski A, Wojakowski W, Buszman PE, Milewski K.Buszman PP, et al.Cardiol J. 2016;23(6):657-666. doi: 10.5603/CJ.2016.0108.Cardiol J. 2016.PMID: 27976797

Differences in vessel healing following delivery of everolimus or paclitaxel: a comparative experimental study using identical stent and biodegradable polymer platforms.

Buszman PP, Milewski K, Pająk J, Jelonek M, Orlik B, Krauze A, Gwiazdowska-Nowotka B, Wojakowski W, Tellez A, Granada JF, Buszman PE.Buszman PP, et al.EuroIntervention. 2014 Oct;10(6):724-31. doi: 10.4244/EIJV10I6A125.EuroIntervention. 2014.PMID: 24469344

Experimental evaluation of pharmacokinetic profile and biological effect of a novel paclitaxel microcrystalline balloon coating in the iliofemoral territory of swine.

Buszman PP, Milewski K, Zurakowski A, Pajak J, Jelonek M, Gasior P, Peppas A, Tellez A, Granada JF, Buszman PE.Buszman PP, et al.Catheter Cardiovasc Interv. 2014 Feb;83(2):325-33. doi: 10.1002/ccd.24982. Epub 2013 Oct 23.Catheter Cardiovasc Interv. 2014.PMID: 23703720

Local intravascular delivery of low-density-lipoprotein cholesterol corresponds with increased intimal thickening in a healthy porcine coronary model. A prelude to development of a model of atherosclerosis.

Buszman PP, Orlik B, Milewski KP, Roleder T, Jelonek M, Polczyk F, Kolodgie FD, Jankowski M, Virmani R, Buszman PE.Buszman PP, et al.Postepy Kardiol Interwencyjnej. 2019;15(1):81-90. doi: 10.5114/aic.2019.83774. Epub 2019 Apr 4.Postepy Kardiol Interwencyjnej. 2019.PMID: 31043989Free PMC article.

Controlled reperfusion with intravenous bivalirudin and intracoronary abciximab combination therapy in the porcine myocardial infarction model.

Buszman PP, Wojakowski W, Milewski K, Dębiński M, Pająk J, Aboodi MS, Jackiewicz W, Kawka M, Bochenek A, Prats J, Granada JF, Kałuża GL, Buszman PE.Buszman PP, et al.Thromb Res. 2012 Aug;130(2):265-72. doi: 10.1016/j.thromres.2011.10.020. Epub 2011 Nov 12.Thromb Res. 2012.PMID: 22079444

Comparison of thin-strut cobalt-chromium stents and stainless steel stents in a porcine model of neointimal hyperplasia.

Milewski K, Zurakowski A, Pajak J, Pajak-Zielinska E, Liszka L, Buszman PP, Bis J, Debinski M, Buszman PE.Milewski K, et al.Med Sci Monit. 2010 Jan;16(1):BR40-4.Med Sci Monit. 2010.PMID: 20037484

Vascular response and mechanical integrity of the new biodegradable polymer coated sirolimus-eluting PROLIM stent implanted in porcine coronary arteries.

Milewski K, Gorycki B, Buszman PP, Jelonek M, Beaudry D, Lapointe JM, Guy LG, Abusamra M, Pająk J, Kinasz W, Wojakowski W, Leclerc G, Gil RJ, Buszman PE.Milewski K, et al.Kardiol Pol. 2012;70(7):703-11.Kardiol Pol. 2012.PMID: 22825946

Temporal healing patterns and coverage dynamics after new Polish transcatheter PFO occluder implantation in a swine.

Milewski K, Fiszer R, Buszman PP, Węglarz P, Janas A, Krauze A, Jelonek M, Hirnle P, Smolka G, Gil R, Białkowski J, Buszman PE.Milewski K, et al. Kardiol Pol. 2017;75(9):907-913. doi: 10.5603/KP.a2017.0117. Epub 2017 Jun 14.Kardiol Pol. 2017.PMID: 28612912

Left Main Stenting in Comparison With Surgical Revascularization: 10-Year Outcomes of the (Left Main Coronary Artery Stenting) LE MANS Trial.

Buszman PE, Buszman PP, Banasiewicz-Szkróbka I, Milewski KP, Żurakowski A, Orlik B, Konkolewska M, Trela B, Janas A, Martin JL, Kiesz RS, Bochenek A. JACC Cardiovasc Interv. 2016

A Nuclear Magnetic Resonance Spectroscopy as a Method for Evaluation of In Vivo Poly-l-Lactide Biodegradation Kinetics From Stent-Polymer Matrices: An Experimental Study Utilizing Porcine Model of In-Stent Restenosis.

Orlik B, Buszman PP, Krauze A, Gąsior P, Desperak P, Pająk J, Kasperczyk J, Janas A, Jelonek M, Handzlik-Orlik G, Buszman PE, Milewski K. J Cardiovasc Pharmacol Ther. 2016

A sirolimus-eluting bioabsorbable polymer-coated stent (MiStent) versus an everolimus-eluting durable polymer stent (Xience) after percutaneous coronary intervention (DESSOLVE III): a randomised, single-blind, multicentre, non-inferiority, phase 3 trial.

de Winter RJ, Katagiri Y, Asano T, Milewski KP, Lurz P, Buszman P, Jessurun GAJ, Koch KT, Troquay RPT, Hamer BJB, Ophuis TO, Wöhrle J, Wyderka R, Cayla G, Hofma SH, Levesque S, Żurakowski A, Fischer D, Kośmider M, Goube P, Arkenbout EK, Noutsias M, Ferrari MW, Onuma Y, Wijns W, Serruys PW. Lancet. 2018 Feb 3;391(10119):431-440. doi: 10.1016/S0140-6736(17)33103-3. Epub 2017 Dec 5.

State-of-the-art of transcatheter treatment of aortic valve stenosis and the overview of the InFlow project aiming at developing the first Polish TAVI system.

Kachel M, Milewski K, Buszman P, Michalak M, Domaradzki W, Gerber W, Śliwka J, Nożyński J, Sobota M, Hirnle P, Białek-Brodocz M, Zembala M, Pawlak M, Płowiecki E, Kasperczyk J, Mężyk A, Bochenek A, Buszman P. Cardiol J. 2017;24(6):685-694. doi: 10.5603/CJ.a2017.0134. Epub 2017 Nov 23.

Safety and feasibility of same-day early discharge after endovascular revascularization of lower extremities in elderly. SENIOR-ER registry.

Janas A, Milewski K, Buszman PP, Janas K, Blachut A, Pruski M, Wiernek S, Zurakowski A, Buszman PE, Kiesz SR. Catheter Cardiovasc Interv. 2018 Feb 15;91(3):515-520. doi: 10.1002/ccd.27338. Epub 2017 Oct 5.

Temporal healing patterns and coverage dynamics after new Polish transcatheter PFO occluder implantation in a swine.

Milewski K, Fiszer R, Buszman PP, Węglarz P, Janas A, Krauze A, Jelonek M, Hirnle P, Smolka G, Gil R, Białkowski J, Buszman PE. Kardiol Pol. 2017;75(9):907-913. doi: 10.5603/KP.a2017.0117. Epub 2017 Jun 14.

Long Term Outcomes in Diabetic Patients Treated With Atherectomy for Peripheral Artery Disease

Adam J Janas, Krzysztof P Milewski, Piotr P Buszman, Wojciech Trendel, Aleksandra Kolarczyk-Haczyk, Mariusz Hochuł, Maciej Pruski Jr, Wojciech Wojakowski, Paweł E Buszman, Radosław S Kiesz Cardiol J 2018 Nov 5. Doi: 10.5603/CJ.a2018.0122.

Safety and Feasibility of Same-Day Early Discharge After Endovascular Revascularization of Lower Extremities in Elderly. SENIOR-ER Registry

Adam Janas, Krzysztof Milewski, Piotr P Buszman, Ksenia Janas, Aleksandra Blachut, Maciej Pruski, Szymon Wiernek, Aleksander Zurakowski, Pawel E Buszman, Stefan R Kiesz Catheter Cardiovasc Interv. 2018 Feb 15;91(3):515-520. doi: 10.1002/ccd.27338. Epub 2017 Oct 5.

Clinical Randomized Trial Evaluating Novel, Microcrystalline, and Biocompatible Polymer Paclitaxel-Coated Balloon for the Treatment of Femoropopliteal Occlusive Disease: The BIOPAC Trial

Buszman PP, Nowakowski P, Milewski K, Orlik B, Żurakowski A, Ludyga T, Polczyk F, Dębiński M, Jelonek M, Kachel M, Gąsior M, Granada JF, Kiesz RS, Buszman PE. JACC Cardiovasc Interv. 2018 Dec 10;11(23):2436-2438. doi: 10.1016/j.jcin.2018.07.029.

Comparison of the Absorb Bioresorbable Vascular Scaffold to the Xience Durable Polymer Everolimus-Eluting Metallic Stent in Routine Clinical Practice: A Propensity Score-Matched Analysis From a Multicenter Registry

Orlik B, Milewski K, Derbisz K, Jelonek M, Chrząszcz P, Beil S, Młodziankowski A, Picheta W, Buszman PP, Buszman PE. Postepy Kardiol Interwencyjnej. 2018;14(2):149-156. doi: 10.5114/aic.2018.76406. Epub 2018 Jun 19.

Peri-procedural hemostasis disorders in surgical and transcatheter aortic valve implantation.

Czerwińska-Jelonkiewicz K, Milewski K, Buszman P, Kwasiborski P, Sanetra K, Domaradzki W, Buszman P. Postępy Kardiol Interwencyjnej. 2019;15(2):176-186. DOI: 10.5114/aic.2019.83649.

Serial comparison of neointimal hyperplasia between the thin strut MiStent with microcrystalline sirolimus and the durable polymer coated everolimus-eluting Xience stent: 6- and 24-month results of DESSOLVE III OCT sub-study.

Milewski K, Takahashi K, Asano T, Katagiri Y, Hochul M, Buszman PP, Tomaniak M, Gorycki B, Zurakowski A, Janas A, Mlodziankowski A, Kachel M, Wykrzykowska JJ, Wijns W, de Winter RJ, Buszman PE, Onuma Y, Serruys PW. EuroIntervention. 2019 May 7. pii: EIJ-D-18-01201. DOI: 10.4244/EIJ-D-18-01201.

Local intravascular delivery of low-density-lipoprotein cholesterol corresponds with increased intimal thickening in a healthy porcine coronary model. A prelude to development of a model of atherosclerosis.

Buszman PP, Orlik B, Milewski KP, Roleder T, Jelonek M, Polczyk F, Kolodgie FD, Jankowski M, Virmani R, Buszman PE. Postępy Kardiol Interwencyjnej. 2019;15(1):81-90. DOI: 10.5114/aic.2019.83774.

The use of modern telemedicine technologies in an innovative optimal cardiac rehabilitation program for patients after myocardial revascularization: Concept and design of RESTORE, a randomized clinical trial.

Milewski K, Małecki A, Orszulik-Baron D, Kachel M, Hirnle P, Orczyk M, Dunal R, Mikołajowski G, Janas A, Nowak Z, Kozak K, Roskiewicz W, Nierwińska K, Izworski A, Rybicki A, Buszman PP, Piotrowicz R, Buszman PE. Cardiol J. 2019;26(5):594-603. DOI: 10.5603/CJ.a2018.0157.

Comparison of long-term outcomes after directional versus rotational atherectomy in peripheral artery disease.

Janas A, Milewski K, Buszman P, Kolarczyk-Haczyk A, Trendel W, Pruski M, Wojakowski W, Buszman P, Kiesz RS.Postepy Kardiol Interwencyjnej. 2020 Mar;16(1):76-81. doi: 10.5114/aic.2020.93914. Epub 2020 Apr 3.PMID: 32368239